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Hepatitis B Vaccine. When is it give? Why is it given? How is it given? Is it safe?

Writer's picture: Informed Choice  MichiganInformed Choice Michigan

Find out the answers to these questions, and more!


According to the CDC recommended vaccine schedule, infants are given the Hepatitis B vaccine in a three-dose series at birth, 1-2 months, and 6-18 months.

But, if you read the footnotes, when given in combination vaccines there can be 4 doses administered instead of just the recommended 3!!!!


"Routine Series:

• A complete series is 3 doses at 0, 1–2, and 6–18

months. (Monovalent HepB vaccine should be

used for doses given before age 6 weeks.)

• Infants who did not receive a birth dose should

begin the series as soon as feasible (see Figure 2).

• Administration of 4 doses is permitted when a

combination vaccine containing HepB is used after

the birth dose.

• Minimum age for the final (3rd or 4th) dose: 24

weeks.

• Minimum Intervals: Dose 1 to Dose 2: 4 weeks /

Dose 2 to Dose 3: 8 weeks / Dose 1 to Dose 3: 16

weeks. (When 4 doses are given, substitute “Dose

4” for “Dose 3” in these calculations.)"


Acute Disseminated Encephalomyelitis following Vaccination against Hepatitis B in a Child: A Case Report and Literature Review



Hepatitis B vaccination of male neonates and autism diagnosis, NHIS 1997-2002


The persistence of anti-HBs antibody and anamnestic response 20 years after primary vaccination with recombinant hepatitis B vaccine at infancy.


Adverse events associated with the hepatitis B vaccine in U.S. children less than six years of age, 1993, and 1994.


A one-year follow-up of chronic arthritis following rubella and hepatitis B vaccination based upon analysis of the Vaccine Adverse Events Reporting System (VAERS) database.


"After reviewing the literature, we observed that complications seen after Hepatitis B vaccination are sudden infant death syndrome, multiple sclerosis, chronic fatigue syndrome, idiopathic thrombocytopenic purpura, vasculitis optic neuritis, anaphylaxis, systemic lupus erythematosus, lichen planus, and neuro-muscular disorder. "

Hepatitis B vaccination and associated oral manifestations: a non-systematic review of literature and case reports


SEVEN-YEAR STUDY OF HEPATITIS B VACCINE EFFICACY IN INFANTS FROM AN ENDEMIC AREA (SENEGAL)


Hepatitis B vaccine induces apoptotic death in Hepa1–6 cells


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